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Vasoactive intestinal peptide (VIP) receptors

Vasoactive intestinal peptide (VIP) receptors are Gs-protein-coupled receptors that consist of two subtypes, VPAC1 and VPAC2, which bind VIP and PACAP with the same affinity.  VIP recptors are widely distributed throughout the central nervous system and are also found in peripheral organs including the liver, lung, intestine, skeletal muscle, heart and kidney. VPAC1 and VPAC2 have diverse biological actions including promotion of neuronal survival, regulation of glycogen metabolism, stimulation of prolactin release from the pituitary and catecholamine release from the adrenal medulla, and inhibition of IL-2-mediated T-cell proliferation. 
Peptides
Cat No. Product Name Activity
VP-020 Bay 55-9837 Selective VPAC2 agonist
VP-010 VIP  Endogenous VPAC1 and VPAC2 agonist.

Further reading

Abad et al (2006) Neuropeptide mimetics and antagonists in the treatment of inflammatory disease: focus on VIP and PACAP. 6(2) 151 PMID: 16454764

Couvineau and Laburthe (2012) VPAC receptors: structure, molecular pharmacology and interaction with accessory proteins. Br J Pharmacol. 166(1) 42 PMID: 21951273

Iwasaki et al (2019) Recent advances in vasoactive intestinal peptide physiology and pathophysiology: focus on the gastrointestinal system. F1000Res. 8 F1000 Faculty Rev-1629 PMID: 31559013

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